Treatment of Toxic Epidermal Necrolysis With Immunoglobulins in a Burn Center
نویسندگان
چکیده
Methods A prospective study has been developed, it included all patients over 16 years old with diagnosis of StevensJohnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) that were admitted to the Burns Critical Unit from Hospital Universitario La Paz, since June 2007 until June 2014. A protocol with a multidisciplinary team was established. The diagnosis was confirmed by biopsy and all of them were treated with immunoglobulins 0.75 g / kg / dx 4 days ( ± 200 grams). Date collected were demographic data, the surface of epidermal detachment, causative drug, SCORTEN, length of stay, complications and mortality.
منابع مشابه
Stevens-johnson Syndrome and Toxic Epidermal Necrolysis in Children: a Literature Review of Current Treatments
Stevens-Johnson syndrome and toxic epidermal necrolysis are among the most concerning drug reactions affecting adults and children. Although the overall mortality has reduced substantially after the introduction of several strategies, such as prompt withdrawal of the causal drug and management of the patients in an intensive care or burn unit, these conditions continue to be associated with sev...
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OBJECTIVES The aims of this review are to summarize the definitions, causes, and clinical course as well as the current understanding of the genetic background, mechanism of disease, and therapy of toxic epidermal necrolysis and Stevens-Johnson syndrome. DATA SOURCES PubMed was searched using the terms toxic epidermal necrolysis, Stevens-Johnson syndrome, drug toxicity, drug interaction, and ...
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Toxic epidermal necrolysis is a severe adverse drug reaction that produces extensive mucocutaneous damage, with full-thickness epidermal detachment, and has many clinical similarities to severe burn injuries. The treatment is mainly supportive and aimed at preventing complications while the disease takes its natural course, and the skin reepithelializes. Much interest exists in the development ...
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Aims: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious severe cutaneous adverse reactions with high mortality and morbidity induced by medications. In this cross sectional study, we investigated, suspected drugs, and potential treatments of SJS/TEN. Methods: A cross- sectional descriptive study was conducted on 60 patients admitted with a diagnosis of Stevens-Jo...
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2015